Baniene R, Trumbeckas D, Kincius M, Pauziene N, Raudone L, Jievaltas M, Trumbeckaite S
Abstract:
Renal artery clamping itself induces renal ischemia which subsequently causes renal cell injury and can lead to renal failure. The duration of warm ischemia that would be safe for postoperative kidney function during partial nephrectomy remains under investigations. Mitochondria play an important role in pathophysiology of ischemia-reperfusion induced kidney injury, however relation between ischemia time and mitochondrial dysfunction are not fully elucidated.
Kuliaviene I, Baniene R, Virketyte S, Kincius M, Jansen E, Gulbinas A, Kupcinskas L, Trumbeckaite S, Borutaite V.
Abstract:
AIMS:
Disturbance of mitochondrial functions has been considered as one of the mechanisms of pathogenesis of acute pancreatitis followed by kidney failure. In this study, we investigated effects of methylene blue on pancreas and kidney mitochondrial respiratory functions during experimental acute pancreatitis in rats.
Meskelevicius Dz, Sidlauskas K, Bagdonaviciute R, Liobikas J and Majiene D
Abstract:
In this study we evaluated the impact of juglone on rat glioma C6 cell culture viability, proliferation and invasiveness in vitro. Juglone induced C6 cell death with EC50 concentrations equal to 10.4 ± 1.6 μM after 24h incubation. At relatively low concentrations juglone significantly decreased cell proliferation, reduced spheroid invasiveness and suppressed “wound” healing. In addition, generation of intracellular reactive oxygen and nitrogen species (RS) was detected in cells treated with juglone.
Trumbeckaite S, Dauksiene J, Bernatoniene J, Janulis V
Abstract:
Traditional medicine therapies are historically used worldwide for disease prevention and treatment purposes. Apitherapy is part of the traditional medicine based on bee product use. Complementary medicine practices which incorporate use of some traditional herbal, mineral, or animal kind substances very often are discussed with pharmacy professionals because these products are often sold in pharmacies as dietary supplements.
Cesna V., Baniene R., Maziukiene A., Kmieliute K., Trumbeckaite S., Venclauskas L., Barauskas G., Gulbinas A.
Abstract:
Activated pancreatic stellate cells (PSC) play a major role in the development of chronic pancreatitis. Flavonoids (C-3-O-G) theoretically may have potential to suppress activated PSC. The aim of our study was to determine the ability of C-3-O-G to invert synthetic and metabolic activity of alcohol stimulated human pancreatic stellate cells (hPSC). In the present study we demonstrate that treatment with C-3-O-G decreased proliferation rate of ethanol activated hPSC by 51%.
