Our articles

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Journal: 

International Journal of Molecular Sciences

Publication Year: 
2021
Authors: 

Gudoityte E, Arandarcikaite O, Mazeikiene I, Bendokas V, Liobikas J.

Abstract: 

Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin.

Platelet Activity and Its Correlation with Inflammation and Cell Count Readings in Chronic Heart Failure Patients with Reduced Ejection Fraction

Journal: 

Medicina (Kaunas)

Publication Year: 
2021
Authors: 

Mongirdiene A, Laukaitiene J, Skipskis V, Kursvietiene L, Liobikas J.

Abstract: 

There has been an increasing interest in the role of inflammation in thrombosis complications in chronic heart failure (HF) patients. The incidence of thrombosis in HF has been shown to be the highest in patients classified as NYHA IV (New York Heart association). It is stated that inflammation is regulated by platelet-induced activation of blood leukocytes.

Increased Succinate Accumulation Induces ROS Generation in In Vivo Ischemia/Reperfusion-Affected Rat Kidney Mitochondria

Journal: 

BioMed Research International

Publication Year: 
2020
Authors: 

Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S.

Abstract: 

Mitochondria are recognized as main reactive oxygen species (ROS) producers, involving ROS generation by mitochondrial complexes I and III. Lately, the focus has been shifting to the ROS generation by complex II. Contribution of complex II (SDH) to ROS generation still remains debatable, especially in in vivo settings.

From the Field to the Antioxidants in the Body

Journal: 

Antioxidants (Basel)

Publication Year: 
2020
Authors: 

Bendokas V, Stanys V, Mažeikienė I, Trumbeckaite S, Baniene R, Liobikas J.

Abstract: 

Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as natural food colorants to be used in yogurts, juices, marmalades, and bakery products. Numerous studies have also indicated the beneficial health effects of anthocyanins and their metabolites on human or animal organisms, including free-radical scavenging and antioxidant activity.

Anthocyanins: from plant pigments to health benefits at mitochondrial level.

Journal: 

Critical Reviews in Food Science and Nutrition

Publication Year: 
2020
Authors: 

Bendokas V, Skemiene K, Trumbeckaite S, Stanys V, Passamonti S, Borutaite V, Liobikas J

Abstract: 

Anthocyanins are water-soluble pigments providing certain color for various plant parts, especially in edible berries. Earlier these compounds were only known as natural food colorants, the stability of which depended on pH, light, storage temperature and chemical structure.

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