Our articles

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Journal: 

Biology (Basel)

Publication Year: 
2022
Authors: 

Mongirdienė A, Liobikas J.

Abstract: 

Chronic heart failure (CHF) results when the heart cannot consistently supply the body’s tissues with oxygen and required nutrients. CHF can be categorized as heart failure (HF) with preserved ejection fraction (HFpEF) or HF with reduced ejection fraction (HFrEF). There are different causes and mechanisms underlying HF pathogenesis; however, inflammation can be regarded as one of the factors that promotes both HFrEF and HFpEF. Monocytes, a subgroup of leukocytes, are known to be cellular mediators in response to cardiovascular injury and are closely related to inflammatory reactions.

Antioxidant and Mitochondria-Targeted Activity of Caffeoylquinic-Acid-Rich Fractions of Wormwood ( Artemisia absinthium L.) and Silver Wormwood ( Artemisia ludoviciana Nutt.)

Journal: 

Antioxidants (Basel)

Publication Year: 
2021
Authors: 

Kamarauskaite J, Baniene R, Raudone L, Vilkickyte G, Vainorien R, Motiekaityte V, Trumbeckaite S.

Abstract: 

Caffeoylquinic acids are some of the chemophenetically significant specialized metabolites found in plants of the family Asteraceae Dumort., possessing a broad spectrum of biological activities. As they might be potential mitochondria-targeted antioxidants, effective preparation methods-including extraction, isolation, and purification of caffeoylquinic acids from plant sources-are in great demand.

The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count

Journal: 

Medicina (Kaunas)

Publication Year: 
2021
Authors: 

Mongirdienė A, Laukaitienė J, Skipskis V, Kuršvietienė L, Liobikas J.

Abstract: 

Background and Objectives: It is known that neutrophils are involved in the pro-inflammatory processes and thus, can have a great impact on the pathophysiology of heart failure (HF). Moreover, hypercholesterolemia heightens neutrophil production, thereby accelerating cardiovascular inflammation. However, there is a lack of information about the relation of low inflammation to the state of stress, hypercholesterolemia, and pro-thrombotic statement in patients with chronic HF.

Caffeic Acid Phenethyl Ester Protects Kidney Mitochondria against Ischemia/Reperfusion Induced Injury in an In Vivo Rat Model

Journal: 

Antioxidants (Basel)

Publication Year: 
2021
Authors: 

Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S.

Abstract: 

To improve ischemia/reperfusion tolerance, a lot of attention has been focused on natural antioxidants. Caffeic acid phenethyl ester (CAPE), an active component of the resinous exudates of the buds and young leaves of Populus nigra L., Baccharis sarothroides A., etc., and of propolis, possesses unique biological activities such as anti-inflammatory, antioxidant, immunomodulating, and cardioprotective effects, among others.

Comparison of Ethanolic and Aqueous-Polyethylenglycolic Propolis Extracts: Chemical Composition and Antioxidant Properties

Journal: 

Evidence-Based Complementary and Alternative Medicine

Publication Year: 
2021
Authors: 

Liaudanskas M, Kubiliene L, Zvikas V, Trumbeckaite S.

Abstract: 

In recent years, particular attention has been paid to the natural antioxidants. Bee products, especially propolis, are characterized by multifunctional (antioxidant, anti-inflammatory, antibacterial, antiviral, and food preservative) effects and can be used for the development of functional food or food preservatives. Propolis extracts that are commonly produced are ethanolic; therefore, to certain groups of consumers, for example, children and alcohol sensitive group, their applicability is limited.

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