Structural and functional properties of human heart atrial appendage mitochondria
Journal:
Publication Year:
2003
Volume:
9 (3)
Pages:
61-66
Abstract:
Objectives: This study has been designed to evaluate disturbances of respiration of atrial appendage mitochondria occurring during heart surgery and their relation with the level of cardiac injury.
Design and Methods: The mitochondrial respiratory parameters were measured in situ,i.e. inatrial appendage fibers of patients with ischemic heart disease undergoing heart surgery under hypothermic the whole heart cardioplegia. Respiratory parameters were analysed together with troponin T (TnT), lactate dehydrogenase (LDH) and creatine kinase (CK) activity in blood.
Results: The study revealed a tight correlation between the maximally elevated activity of LDH in the blood (sampled after the cardiac operations) and two respiratory parameters of atrial appendage mitochondria (both measured before cardioplegia), – respiratory control index (negative, r=−0.61) and percentage of atractyloside-insensitive respiration (positive, r=0.80).
Conclusions:The data obtained in this work allow us to conclude that investigation of respiration of atrial appendage mitochondria can be applied for the assessment of the disturbances in the whole heart mitochondria occurring during heart surgery and, that their studies before cardioplegia may provide useful information for the prognosis of cardiac cell energetics, function disturbances and recovery after cardioplegia.
Other publications written by: